Childhood stressors

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: National Institute on Aging

Humans2

Outcomes

Memory decline over time

no changein humans1

1 study

Childhood stressors have no effect on memory decline over time in humans.
“childhood stressors were not significantly associated with memory decline over time.”
Humansn = 9,069
Effects of Childhood Stressors on Memory: Mediating Role of Psychological Resilience
GSA 2025 abstract31 Dec 2025

Associations

Cognitive function

downin humans1

1 study

Childhood stressors predict cognitive function in humans.
“Greater childhood stressors predicted worse cognitive function among Early Baby Boomer cohort only.”
HumansEarly Baby Boomer cohort (1948-1953)n = 10,757
The impact of childhood and adulthood stressors on later-life cognitive function: evaluating birth cohort differences
Longitudinal and life course studies : international journal16 Mar 2026

Baseline memory performance

upin humans1

1 study

Childhood stressors are associated with baseline memory performance in humans (β = 0.12, p < .001).
“respondents who reported a greater number of childhood stressors had higher baseline memory performance (β = 0.12, p < .001).”
Humansn = 9,069
Effects of Childhood Stressors on Memory: Mediating Role of Psychological Resilience
GSA 2025 abstract31 Dec 2025