Cascade screening

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Humans1

Outcomes

2

Age at diagnosis

downin humans1

1 study
  1. Cascade screening decreases age at diagnosis in humans (~9 years earlier).

    Humanscarrier relatives compared with index cases

    Cascade screening amplifies familial hypercholesterolaemia detection after clinically guided next- generation sequencing

    Research Square12 Aug 2026Preprint

Carrier relative identification

upin humans1

1 study
  1. Cascade screening increases carrier relative identification in humans (68.2% (133/195), 2.6 per index case).

    Humansrelatives of genetically confirmed casesn = 195

    Cascade screening amplifies familial hypercholesterolaemia detection after clinically guided next- generation sequencing

    Research Square12 Aug 2026Preprint

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