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Captivity

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Diastolic function

downin rhesus monkeys1

1 study

  1. Captivity impairs diastolic function in rhesus monkeys.

    “Compared with captive macaques, free-ranging animals exhibited better diastolic function, including a significantly higher E/A ratio, greater e', and lower a'.”

    Animalsacross ageheart

    The influence of captivity on cardiac structure and function across age, in rhesus macaques

    bioRxiv : the preprint server for biology21 Oct 2025Preprint

Relative wall thickness

upin rhesus monkeys1

1 study

  1. Captivity increases relative wall thickness in rhesus monkeys.

    “Captive macaques also had significantly greater relative wall thickness across age and between sexes.”

    Animalsacross ageheart

    The influence of captivity on cardiac structure and function across age, in rhesus macaques

    bioRxiv : the preprint server for biology21 Oct 2025Preprint

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