Beta-lactolin
Beta-lactolin has been studied in 2 papers since 2021: none in people yet, 1 in animals, 1 review. The research so far is in animals. The newest paper, Jan 1, 2022: “Effect of Whey-Derived Lactopeptide β-Lactolin on Memory in Healthy Adults: An Integrated Analysis of Data from Randomized Controlled Trials”.
“As a result of integrating the effect sizes by the meta-analysis method, the effect size of β-lactolin compared with the placebo was positive, but not significant.”
None of its findings points the other way.
- 2 independent labs in 1 country
- Funder: Japan Society for the Promotion of Science
- 9 of 9 findings with company ties
- Animals1
Studies in people
1 study gave beta-lactolin to people and measured what changed.
no change: Has no effect on memory
up: Improves cued recallg=0.33, 95% CI 0.10 to 0.55
no change: Has no effect on free recallg=−0.06, 95% CI −0.23 to 0.11
Review of trials232 people pooled36.2% of all participants were maleaverage age 56.2 years6 or 12 weeks
The journal of nutrition, health & aging, Jan 1, 2022
What did studies of Beta-lactolin find?
8Studies of Beta-lactolin measured 8 outcomes; the most studied are cued recall (1 study), free recall (1) and memory (1).
Cued recall
upin humans1
1 study
Cued recall
upin humans1
Beta-lactolin improves cued recall in humans (g=0.33, 95% CI 0.10 to 0.55).
“The integrated analysis revealed that β-lactolin significantly improved cued recall compared with the placebo (g=0.33; 95% CI 0.10 to 0.55, z=2.85, P=0.004), with low heterogeneity between studies (I2=38%, P=0.20).”
Human trialtablets6 or 12 weeksn = 232
The journal of nutrition, health & aging
Beta-lactolin improves cued recall in humans (g=0.33; 95% CI: 0.10, 0.55).
“the score of cued recall among the neuropsychological tests in the β-lactolin group was significantly higher than that in the placebo group (g=0.33; 95% CI: 0.10, 0.55)”
Human trialhealthy adults
The journal of nutrition, health & aging
Free recall
no changein humans1
1 study
Free recall
no changein humans1
Beta-lactolin has no effect on free recall in humans (g=−0.06, 95% CI −0.23 to 0.11).
“The composite effect size for free recall was computed to evaluate the efficacy of β-lactolin on free recall. β-lactolin had no significant effect on free recall compared to the placebo (g=−0.06; 95% CI −0.23 to 0.11, z=0.66, P=0.51), with low heterogeneity between studies (I2=0%, P=0.92).”
Human trialtablets6 or 12 weeksn = 232
The journal of nutrition, health & aging
Memory
no changein humans1
1 study
Memory
no changein humans1
Beta-lactolin has no effect on memory in humans.
“As a result of integrating the effect sizes by the meta-analysis method, the effect size of β-lactolin compared with the placebo was positive, but not significant.”
Human trialtablets6 or 12 weeksn = 232
The journal of nutrition, health & aging
Cytochrome C
downin mice1
1 study
Cytochrome C
downin mice1
Beta-lactolin decreases cytochrome C in mice.
“Cytochrome c levels in the hippocampus and cortex were increased in aged mice compared with those in young mice but were also reduced by β-lactolin consumption.”
Animalsaged micehippocampus and cortex
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
Frontiers in nutrition
Hippocampal atrophy
downin mice1
1 study
Hippocampal atrophy
downin mice1
Beta-lactolin decreases hippocampal atrophy in mice.
“The age-related hippocampal atrophy was improved in aged mice fed β-lactolin.”
Animalsaged micehippocampus
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
Frontiers in nutrition
Inflammation
downin mice1
1 study
Inflammation
downin mice1
Beta-lactolin decreases inflammation in mice.
“These results suggest that β-lactolin consumption prevents neural inflammation and alleviates aging-related cognitive decline.”
Animalsaged micehippocampus and cortex
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
Frontiers in nutrition
Light/dark activity cycles
upin mice1
1 study
Light/dark activity cycles
upin mice1
Beta-lactolin improves light/dark activity cycles in mice.
“In aged mice, impairment of light/dark activity cycles was found to be induced, which was subsequently alleviated by β-lactolin consumption.”
Animalsaged mice
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
Frontiers in nutrition
Object recognition memory
upin mice1
1 study
Object recognition memory
upin mice1
Beta-lactolin improves object recognition memory in mice.
“in aged mice fed β-lactolin for 3 months, memory impairment was subsequently alleviated.”
Animalsaged mice3 months
β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline
Frontiers in nutrition