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Epigallocatechin gallate + beta-alanine

Epigallocatechin gallate + beta-alanine has been studied in 1 paper since 2017: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 14, 2017: “Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice”.

Intervention

1 paper studies it1 more mentions it4 findingsUpdated

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None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Abbott and 1 more
  • Animals1

What did studies of Epigallocatechin gallate + beta-alanine find?

4

Studies of Epigallocatechin gallate + beta-alanine measured 4 outcomes; the most studied are time to exhaustion in a treadmill fatigue test (1 study), rotarod performance (1) and cognitive function (1).

Time to exhaustion in a treadmill fatigue test

downin mice1

1 study

  1. Epigallocatechin gallate + beta-alanine impairs time to exhaustion in a treadmill fatigue test in mice (p=0.02).

    “decreased time to exhaustion in a treadmill fatigue test (p=0.02) compared to Ctrl.”

    Animals6 months

    Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

    Experimental gerontology

Rotarod performance

upin mice1

1 study

  1. Epigallocatechin gallate + beta-alanine improves rotarod performance in mice (p=0.03).

    “E+B increased rotarod performance (p=0.03), did not affect grip strength (p=0.91), and decreased time to exhaustion in a treadmill fatigue test (p=0.02) compared to Ctrl.”

    Animals6 months

    Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

    Experimental gerontology

Cognitive function

no changein mice1

1 study

  1. Epigallocatechin gallate + beta-alanine has no effect on cognitive function in mice (p=0.74, p=0.16).

    “E+B did not affect arm preference in the Y-maze test (p=0.74, novel arm) and did not alter performance in an active avoidance test (p=0.16, avoidances per 50 trials).”

    Animals6 months

    Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

    Experimental gerontology

Mortality

downin mice1

1 study

  1. Epigallocatechin gallate + beta-alanine decreases mortality in mice (80% vs 40% survival, p=0.02).

    “Interestingly, a higher percentage of mice receiving EGCG and B-ALA (E+B, 80%) survived to study end compared to control (Ctrl, 40%) mice (p=0.02).”

    Animals6 months

    Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

    Experimental gerontology

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