Bet inhibitors
Intervention1 paper4 findings
- Animals1
Outcomes
4Lifespan
upin mice1Very low certainty
1 study
Lifespan
upin mice1Very low certainty
Bet inhibitors extend lifespan in mice.
“delays epigenetic aging, and promotes better survival in aged mice”
Animalsaged mice14 weeks
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging · GSA 2025 abstract · 31 Dec 2025
Epigenetic aging
downin mice1Very low certainty
1 study
Epigenetic aging
downin mice1Very low certainty
Bet inhibitors decrease epigenetic aging in mice.
“delays epigenetic aging, and promotes better survival in aged mice”
Animalsaged mice14 weeks
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging · GSA 2025 abstract · 31 Dec 2025
Memory function
upin mice1Very low certainty
1 study
Memory function
upin mice1Very low certainty
Bet inhibitors improve memory function in mice.
“treatment with BET inhibitor effectively suppresses age-associated decline in muscle strength, body balance, and memory function”
Animalsaged mice14 weeks
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging · GSA 2025 abstract · 31 Dec 2025
Muscle strength
upin mice1Very low certainty
1 study
Muscle strength
upin mice1Very low certainty
Bet inhibitors improve muscle strength in mice.
“treatment with BET inhibitor effectively suppresses age-associated decline in muscle strength, body balance, and memory function”
Animalsaged miceskeletal muscle14 weeks
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging · GSA 2025 abstract · 31 Dec 2025