Rho iso-alpha acids + berberine + vitamin D3 + vitamin K1

1. Rho iso-alpha acids + berberine + vitamin D3 + vitamin K1 increases PINP in humans (significant increase).

   “the intervention arm exhibited a significant increase in amino-terminal propeptide of type I collagen, whereas the placebo arm showed a significant decrease at 14 weeks.”

   Human trialmetabolic syndrome, highest tertile of baseline insulin-like growth factor Iserum14 weeksfemales

   Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

   Nutrition research (New York, N.Y.)·Apr 29, 2011

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1. Rho iso-alpha acids + berberine + vitamin D3 + vitamin K1 increases 25-hydroxyvitamin D in humans (+23%).

   “Serum 25-hydroxyvitamin D increased 23% (P = .001) in the intervention arm and decreased 12% (P = .03) in the placebo arm.”

   Human trialmetabolic syndromeserum14 weeksfemalesn = 25

   Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

   Nutrition research (New York, N.Y.)·Apr 29, 2011

More on 25-hydroxyvitamin D

1. Rho iso-alpha acids + berberine + vitamin D3 + vitamin K1 decreases osteocalcin in humans (approximate 25% mean decrease).

   “Compared with baseline, the intervention arm exhibited an approximate 25% mean decrease (P < .001) in serum osteocalcin”

   Human trialmetabolic syndromeserum14 weeksfemalesn = 25

   Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D₃, and vitamin K₁ produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome

   Nutrition research (New York, N.Y.)·Apr 29, 2011

More on Osteocalcin