Aortic stiffening

Aortic stiffening increases left ventricular end-diastolic and end-systolic volumes in silico.

“In phase I, EDV and ESV increased, as did SW and PVA.”

In silicoNormal-to-stiff aortic compliance settings at a heart rate of 80 bpmleft ventricle

Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in cardiovascular medicine·Mar 27, 2024

Aortic stiffening decreases left ventricular mechanical efficiency in silico (71.5% to 60.8%).

“ME decreased from 71.5 to 60.8%, respectively.”

In silicoNormal-to-stiff aortic compliance settings at a heart rate of 80 bpmleft ventricle

Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in cardiovascular medicine·Mar 27, 2024

Aortic stiffening is associated with ventricular contractile-state parameters in silico.

“The impact on the CS parameters demonstrated a small decrease in ESPVR, no change in dP/dtmax-EDV, and a large increase in PRSW.”

In silicoNormal-to-stiff aortic compliance settings at a heart rate of 80 bpmmyocardium

Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in cardiovascular medicine·Mar 27, 2024