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Anticholinergics and sedatives

Anticholinergics and sedatives has been studied in 2 papers since 2025: 2 observational studies in people; 1 in the past year. The newest paper, Nov 6, 2025: “Anticholinergic and sedative medications use among community dwelling older adults: risk for polypharmacy and poor physical function”.

Intervention

2 papers study it4 findingsUpdated

See all 2

“The AUC DBI/days was associated with falls (aOR 1.29, 95% CI: 1.18-1.41), delirium (aOR 1.63, 95% CI:1.46-1.82)”
Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatientsAge and ageing2025doi:10.1093/ageing/afaf270

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Humans2

What is Anticholinergics and sedatives linked with?

4

Studies link Anticholinergics and sedatives with 4 measures, most often pressure ulcer (1 study), frailty (1) and falls (1).

Pressure ulcer

upin humans1OR 1.6

1 study

  1. Anticholinergics and sedatives are associated with pressure ulcer in humans (older surgical inpatients) (OR 1.60, 95% CI: 1.38-1.86).

    “pressure ulcers (OR 1.60, 95% CI: 1.38-1.86)”

    Humansolder surgical inpatientsn = 13,815

    Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatients

    Age and ageing

More on Pressure ulcer

Frailty

upin humans1

1 study

  1. Anticholinergics and sedatives are associated with frailty in humans (older surgical inpatients) (aRR 1.27, 95% CI: 1.17-1.37).

    “HFRS (aRR 1.27, 95% CI:1.17-1.37) and increased LOS (aRR 1.36, 95% CI:1.32-1.40)”

    Humansolder surgical inpatientsn = 13,815

    Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatients

    Age and ageing

Falls

upin humans1

1 study

  1. Anticholinergics and sedatives are associated with falls in humans (older surgical inpatients) (aOR 1.29, 95% CI: 1.18-1.41).

    “The AUC DBI/days was associated with falls (aOR 1.29, 95% CI: 1.18-1.41)”

    Humansolder surgical inpatientsn = 13,815

    Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatients

    Age and ageing

Delirium

upin humans1

1 study

  1. Anticholinergics and sedatives are associated with delirium in humans (older surgical inpatients) (aOR 1.63, 95% CI: 1.46-1.82).

    “The AUC DBI/days was associated with falls (aOR 1.29, 95% CI: 1.18-1.41), delirium (aOR 1.63, 95% CI:1.46-1.82)”

    Humansolder surgical inpatientsn = 13,815

    Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatients

    Age and ageing

More on Delirium

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