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Anisotropic topographies

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Berlin Institute of Health and 2 more
  • Cells1

Outcomes

3

YAP1

upin human cells1

1 study

  1. Anisotropic topographies activate YAP1 in human cells.

    “enhanced yes-associated protein nuclear translocation”

    Cellssenescent endothelial cells

    Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells

    Frontiers in cardiovascular medicineOct 5, 2022

More on YAP1

Cell proliferation

upin human cells1

1 study

  1. Anisotropic topographies increase cell proliferation in human cells.

    “enhanced yes-associated protein nuclear translocation and cell proliferation”

    Cellssenescent endothelial cells

    Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells

    Frontiers in cardiovascular medicineOct 5, 2022

Adherens junction integrity

upin human cells1

1 study

  1. Anisotropic topographies improve adherens junction integrity in human cells.

    “After cultivation on gridded surfaces, the cells showed significant improvements in terms of adherens junction integrity, cell elongation, and orientation of the actin filaments”

    Cellssenescent endothelial cells

    Anisotropic topographies restore endothelial monolayer integrity and promote the proliferation of senescent endothelial cells

    Frontiers in cardiovascular medicineOct 5, 2022

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