Ampakines
Ampakines has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Feb 3, 2016: “Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats”.
1 paper studies it3 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of Neurological Disorders and Stroke and 4 more
- Animals1
What did studies of Ampakines find?
3Studies of Ampakines measured 3 outcomes; the most studied are long-term memory (1 study), long-term potentiation (1) and dendritic retraction (1).
Long-term memory
upin rats1
1 study
Long-term memory
upin rats1
Ampakines improve long-term memory in rats.
“Dendritic recovery was accompanied by improvements to both synaptic plasticity and the encoding of long-term memory of a novel, complex environment.”
Animalsnovel, complex environment; housed in an enriched environmentshort half-lifedaily3 months
Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats
The Journal of neuroscience : the official journal of the Society for Neuroscience
Long-term potentiation
upin rats1
1 study
Long-term potentiation
upin rats1
Ampakines increase long-term potentiation in rats.
“long-term potentiation was greater in ampakine-treated rats.”
Animalshoused in an enriched environmentshort half-lifeCA1daily3 months
Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dendritic retraction
downin rats1
1 study
Dendritic retraction
downin rats1
Ampakines decrease dendritic retraction in rats.
“dendritic losses are evident by middle age despite housing in an enriched environment and can be mostly reversed by long-term, oral administration”
Animalshoused in an enriched environmentshort half-lifeCA1 pyramidal neuronsdaily3 months
Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats
The Journal of neuroscience : the official journal of the Society for Neuroscience