Amlodipine + folic acid

1. Amlodipine + folic acid has no effect on adverse events in humans.

   “There was no significant difference in BP lowering and adverse events among the three treatment groups.”

   Human trialH-type hypertension; compared with amlodipine alone5 mg amlodipine plus 0.4 mg or 0.8 mg folic acid8 weeksn = 540

   Blood pressure and homocysteine-lowering effects of the amlodipine/folic acid combination in patients with hypertension and serum homocysteine concentration ≥10 μmol/l (H-type hypertension): a multicenter, randomized, double-blind, parallel-controlled clinical trial

   Journal of hypertension·31 Aug 2026

1. Amlodipine + folic acid has no effect on blood pressure lowering in humans.

   “There was no significant difference in BP lowering and adverse events among the three treatment groups.”

   Human trialH-type hypertension; compared with amlodipine alone5 mg amlodipine plus 0.4 mg or 0.8 mg folic acid8 weeksn = 540

   Blood pressure and homocysteine-lowering effects of the amlodipine/folic acid combination in patients with hypertension and serum homocysteine concentration ≥10 μmol/l (H-type hypertension): a multicenter, randomized, double-blind, parallel-controlled clinical trial

   Journal of hypertension·31 Aug 2026

1. Amlodipine + folic acid increases folate in humans.

   “Both groups B and C were more efficacious in lowering Hcy and raising folate levels than amlodipine alone at 8 weeks.”

   Human trialH-type hypertension; compared with amlodipine alone5 mg amlodipine plus 0.4 mg or 0.8 mg folic acid8 weeksn = 540

   Blood pressure and homocysteine-lowering effects of the amlodipine/folic acid combination in patients with hypertension and serum homocysteine concentration ≥10 μmol/l (H-type hypertension): a multicenter, randomized, double-blind, parallel-controlled clinical trial

   Journal of hypertension·31 Aug 2026

More on Folate

1. Amlodipine + folic acid decreases homocysteine in humans.

   “Both groups B and C were more efficacious in lowering Hcy and raising folate levels than amlodipine alone at 8 weeks.”

   Human trialH-type hypertension; compared with amlodipine aloneplasma5 mg amlodipine plus 0.4 mg or 0.8 mg folic acid8 weeksn = 540

   Blood pressure and homocysteine-lowering effects of the amlodipine/folic acid combination in patients with hypertension and serum homocysteine concentration ≥10 μmol/l (H-type hypertension): a multicenter, randomized, double-blind, parallel-controlled clinical trial

   Journal of hypertension·31 Aug 2026

More on Homocysteine

1. Amlodipine + folic acid increases combined blood pressure and homocysteine lowering efficacy in humans (0.4 mg folic acid combination: 31.7% vs. 6.1%; 0.8 mg combination: 32.8% vs. 6.1%; both P < 0.001).

   “had a significantly higher efficacy of lowering both BP and plasma Hcy compared with amlodipine alone.”

   Human trialH-type hypertension; compared with 5 mg amlodipine alone5 mg amlodipine plus 0.4 mg or 0.8 mg folic acid8 weeksn = 540

   Blood pressure and homocysteine-lowering effects of the amlodipine/folic acid combination in patients with hypertension and serum homocysteine concentration ≥10 μmol/l (H-type hypertension): a multicenter, randomized, double-blind, parallel-controlled clinical trial

   Journal of hypertension·31 Aug 2026