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Adverse relationships

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Associations

2

Onset of disability

upin humans1

1 study

  1. Adverse relationships are associated with onset of disability in humans (β = -0.07, p < 0.001).

    “Over time, early onset of disability was associated with adverse (β = -0.07, p < 0.001) and ambivalent relationships (β = -0.07, p < 0.001).”

    Humans12-14 years

    RELATIONSHIP QUALITY PATTERNS AND DISABILITY IN LATER LIFE

    GSA 2024 abstract31 Dec 2024

Disability

upin humans1OR 1.26

1 study

  1. Adverse relationships raise the risk of disability in humans (OR=1.26, 95% CI=1.11-1.44).

    “At W1, older adults in adverse relationships had higher odds of disability than older adults in high quality relationships (OR=1.26, 95% CI=1.11-1.44).”

    Humans

    RELATIONSHIP QUALITY PATTERNS AND DISABILITY IN LATER LIFE

    GSA 2024 abstract31 Dec 2024

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