AAV9-CAMKIICA

Intervention1 paper2 findings

  • Animals1

Outcomes

2

Compound muscle action potential

downin mice1Very low certainty

1 study

  1. AAV9-CAMKIICA decreases compound muscle action potential in mice.

    “muscles expressing CaMKIICA had a subtle but significant reduction of compound muscle action potential (CMAP)”

    Animalsexpressed in tibialis anterior musclesconstitutively active CaMKIItibialis anterior

    CAMKII HYPERACTIVATION IN SKELETAL MUSCLES IS A DRIVER AND POTENTIAL THERAPEUTIC TARGET OF SARCOPENIA · GSA 2024 abstract · 31 Dec 2024

Compound muscle action potential →

Muscle contractile force

downin mice1Very low certainty

1 study

  1. AAV9-CAMKIICA impairs muscle contractile force in mice.

    “when we expressed a constitutively active CaMKII (CaMKIICA) in the TA muscles of young mice (3-month-old), we observed a striking reduction of muscle contractility.”

    Animalsexpressed in tibialis anterior musclesconstitutively active CaMKIItibialis anterior

    CAMKII HYPERACTIVATION IN SKELETAL MUSCLES IS A DRIVER AND POTENTIAL THERAPEUTIC TARGET OF SARCOPENIA · GSA 2024 abstract · 31 Dec 2024

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