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Aav-minidystrophin

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Muscular Dystrophy Association and 1 more
  • Animals1

Outcomes

4

Muscle pathologies

downin mice1

1 study

  1. Aav-minidystrophin decreases muscle pathologies in mice.

    “ameliorated muscle pathologies”

    Animalsin mdx and dKO mice

    Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Apr 2009

Spine and limb deformation

downin mice1

1 study

  1. Aav-minidystrophin prevents spine and limb deformation in mice.

    “inhibition of spine and limb deformation”

    Animalsin mdx and dKO mice

    Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Apr 2009

Motility

upin mice1

1 study

  1. Aav-minidystrophin improves motility in mice.

    “improvement in growth and motility”

    Animalsin mdx and dKO mice

    Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Apr 2009

Lifespan

upin mice1

1 study

  1. Aav-minidystrophin extends lifespan in mice.

    “prolongation of life span”

    Animalsin mdx and dKO mice

    Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Apr 2009

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