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1,3-butanediol

Intervention

1 paper1 finding

PubChem 7896ChEBI 52683

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 1 more
  • Animals1

Mouse lifespan

NIA ITP

Outcomes

1

Lifespan

upin mice1+2%

1 study

  1. 1,3-butanediol extends lifespan in mice (2%).

    “BD seemed to produce a small (2%) increase in females, but only if the analysis included data from the site with unusually short-lived controls.”

    Animalsfemales

    Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

    Aging cell30 Sep 2022

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