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VANGL2

Gene

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Agence Nationale de la Recherche and 3 more
  • Animals1

Effects

2

Cognitive flexibility

downin mice1

1 study

  1. VANGL2 impairs cognitive flexibility in mice.

    “advances the onset of a decrease in cognitive flexibility”

    Animalsheterozygous dominant-negative Looptail mutation

    Vangl2, a Core Component of the WNT/PCP Pathway, Regulates Adult Hippocampal Neurogenesis and Age-Related Decline in Cognitive Flexibility

    Frontiers in aging neuroscienceMar 9, 2022

Survival of adult-born granule cells

downin mice1

1 study

  1. VANGL2 decreases survival of adult-born granule cells in mice.

    “alteration in Vangl2 expression decreases the survival of adult-born granule cells”

    Animalsheterozygous dominant-negative Looptail mutationdentate gyrus

    Vangl2, a Core Component of the WNT/PCP Pathway, Regulates Adult Hippocampal Neurogenesis and Age-Related Decline in Cognitive Flexibility

    Frontiers in aging neuroscienceMar 9, 2022

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