Cell Biology and Toxicology
Lowering a protein improved heart relaxation in aged mice
Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.Mice given a heart-cell-targeted gene-silencing injection at 90 weeks had less inflammation and better heart relaxation when assessed at 110 weeks.
Mouse studyMechanisms
Who was studiedNaturally aged mice of both sexes
What changedLowering TRAF1 improved heart relaxation in aged mice
The catchHeart relaxation was inferred from E/A and E/e′ ratios