There is 1 paper on TAF4B in aging research: none in people yet, 1 in animals.
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Brown University and 5 more
- Animals1
Effects
4SMC1B
upin mice1
1 study
SMC1B
upin mice1
TAF4B increases SMC1B in mice (Taf4b knockout).
“revealing several molecular signatures of premature reproductive senescence, including reduced Smc1b.”
AnimalsTaf4b knockoutovaryfemales
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice
Biology of reproduction
MOV10L1
upin mice1
1 study
MOV10L1
upin mice1
TAF4B increases MOV10L1 in mice (Taf4b knockout).
“One significantly reduced transcript in the young TAF4B-null ovary codes for MOV10L1”
AnimalsTaf4b knockoutovaryfemales
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice
Biology of reproduction
Ovarian function
downin mice1
1 study
Ovarian function
downin mice1
TAF4B protects against ovarian function in mice (Taf4b knockout).
“The rapid decline of ovarian function in Taf4b-null mice begins in early postnatal life, and follicle depletion is completed by 16 wk of age.”
AnimalsTaf4b knockoutovaryfemales
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice
Biology of reproduction
Reproductive senescence
downin mice1
1 study
Reproductive senescence
downin mice1
TAF4B prevents reproductive senescence in mice (Taf4b knockout).
“we show that TAF4B-deficient female mice exhibit premature reproductive senescence.”
AnimalsTaf4b knockoutovaryfemales
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice
Biology of reproduction