ss

1. ss decreases oxidative stress and ROS signalling in flies.

   “Furthermore, oxidative stress assays showed that ss flies are more stress resistant, significantly outliving the wildtype flies at an early age.”

   Model organismsshown by deficiency conferring resistance

   EFFECTS OF SPINELESS ON SURVIVAL AND REPRODUCTION IN DROSOPHILA MELANOGASTER · GSA 2024 abstract · 31 Dec 2024

Oxidative stress and ROS signalling →

1. ss mediates lifespan in flies.

   “The lifespan-shortening effects of tryptophan metabolites were reduced in ss-deficient flies, suggesting that the negative effects of tryptophan metabolites may be dependent on ss.”

   Model organismslifespan shortening by tryptophan metabolites

   EFFECTS OF SPINELESS ON SURVIVAL AND REPRODUCTION IN DROSOPHILA MELANOGASTER · GSA 2024 abstract · 31 Dec 2024