SIK2

1. SIK2 decreases UCP1.

   “salt-inducible kinases (SIK2/3), as transcriptional repressors that limit UCP-1 expression when β3-adrenergic/protein kinase A (PKA) signaling is impaired”

   Reviewwhen beta3-adrenergic/PKA signaling is impaired

   Mechanistic drivers of thermogenic adipose tissue dysfunction in aging and obesity

   American journal of physiology. Endocrinology and metabolism·17 Aug 2026

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