semi-1

1. semi-1 improves selenite resistance in worms.

   “On the other hand, they show enhanced susceptibility to selenite exposure, indicating a role for SEMI-1 in conferring selective stress resistance.”

   Model organismsshown by SEMI-1 deficiency under selenite exposure

   SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans

   BioFactors (Oxford, England)·1 Jan 2026

1. semi-1 increases age pigment accumulation in worms.

   “Depletion of SEMI-1 results in increased lifespan, improved physiological parameters (motility, progeny), and reduced accumulation of age pigments during aging.”

   Model organismsshown by SEMI-1 depletionduring aging

   SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans

   BioFactors (Oxford, England)·1 Jan 2026

More on Age pigment accumulation

1. semi-1 shortens lifespan in worms.

   “Depletion of SEMI-1 results in increased lifespan, improved physiological parameters (motility, progeny), and reduced accumulation of age pigments during aging.”

   Model organismsshown by SEMI-1 depletion

   SEMI-1, A Novel Neuronal Selenium-Binding Protein 1 Homolog Without Methanethiol Oxidase Activity, Modulates Stress Resistance, Lifespan, and Thermotaxis in C. elegans

   BioFactors (Oxford, England)·1 Jan 2026