PGRMC2
- 1 lab in 1 country
- Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 4 more
- Animals1
Effects
3Reproductive lifespan
is required forin mice1
1 study
Reproductive lifespan
is required forin mice1
PGRMC2 is required for reproductive lifespan in mice.
“Pgrmc1 and/or Pgrmc2 are required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan”
Animalsfemales
EndocrinologyMar 1, 2017
Litters
downin mice1−38% fewer litters
1 study
Litters
downin mice1−38% fewer litters
PGRMC2 decreases litters in mice (37.8% fewer litters).
“producing 37.8% fewer litters overall during the trial compared with Pgrmc2fl/fl mice (P = 0.020)”
Animalsconditional ablation (Pgrmc2d/d)females
EndocrinologyMar 1, 2017
Pups per litter
downin mice1−47% fewer pups/litter
1 study
Pups per litter
downin mice1−47% fewer pups/litter
PGRMC2 decreases pups per litter in mice (47% fewer pups/litter).
“Pgrmc2d/d female mice producing 47% fewer pups/litter than Pgrmc2fl/fl mice (P = 0.001)”
Animalsconditional ablation (Pgrmc2d/d)females
EndocrinologyMar 1, 2017