AgingResearch.NewsJoin free

pdi-6

Gene

1 paper4 findings

Taxon 6239

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Chinese Academy of Sciences and 5 more
  • Model organisms1

Effects

3

Lifespan

downin worms1upin worms1

1 study

  1. pdi-6 shortens lifespan in worms.

    “animals with pdi-6 deficiency have decreased lifespan.”

    Model organismsdeficiency

    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans

    Cell reports7 Jun 2022

  2. pdi-6 extends lifespan in worms.

    “Overexpression of PDI-6 is sufficient to maintain Wnt/EGL-20 protein levels during aging, activating the UPRmt, and significantly extending lifespan in a Wnt- and UPRmt-dependent manner.”

    Model organismsoverexpression

    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans

    Cell reports7 Jun 2022

egl-20

downin worms1

1 study

  1. pdi-6 decreases egl-20 in worms.

    “pdi-6 deficiency results in misfolded EGL-20, which leads to its degradation via ER-associated protein degradation (ERAD) machinery.”

    Model organismspdi-6 deficiency

    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans

    Cell reports7 Jun 2022

More on egl-20

Mitochondrial unfolded protein response

upin worms1

1 study

  1. pdi-6 activates mitochondrial unfolded protein response in worms.

    “Overexpression of PDI-6 is sufficient to maintain Wnt/EGL-20 protein levels during aging, activating the UPRmt”

    Model organismsoverexpression

    Protein disulfide isomerase PDI-6 regulates Wnt secretion to coordinate inter-tissue UPRmt activation and lifespan extension in C. elegans

    Cell reports7 Jun 2022

More on Mitochondrial unfolded protein response

Latest

Related