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npr-28

There is 1 paper on npr-28 in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it2 findings

NCBI GeneTaxon

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Model organisms1

Effects

1

Behavioral deterioration

upin worms1

1 study

  1. npr-28 increases behavioral deterioration in worms (NPR-28 signalling acting in serotonergic and dopaminergic neurons).

    “Glia-derived RGBA-1 activates NPR-28 signalling, which acts in serotonergic and dopaminergic neurons to accelerate behavioural deterioration”

    Model organismsNPR-28 signalling acting in serotonergic and dopaminergic neurons

    Genetic variation in glia-neuron signalling modulates ageing rate

    Nature

Associations

1

Rate of age-related decline of mating behavior

mixedin worms1

1 study

  1. npr-28 is associated with rate of age-related decline of mating behavior in worms (natural genetic variation among isolates).

    “DNA polymorphisms in a novel peptide-coding gene, named regulatory-gene-for-behavioural-ageing-1 (rgba-1), and the neuropeptide receptor gene npr-28 influence the rate of age-related decline of worm mating behaviour”

    Model organismsnatural genetic variation among isolates

    Genetic variation in glia-neuron signalling modulates ageing rate

    Nature

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