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NCSTN

Gene

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 6 more
  • Animals1

Effects

2

Bone repair

downin mice1

1 study

  1. NCSTN impairs bone repair in mice.

    “Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair.”

    AnimalsNicastrin deletion in SSPCs

    Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

    Bone researchSep 27, 2023

Bone marrow adiposity

upin mice1

1 study

  1. NCSTN increases bone marrow adiposity in mice.

    “Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair.”

    AnimalsNicastrin deletion in SSPCs

    Loss of Notch signaling in skeletal stem cells enhances bone formation with aging

    Bone researchSep 27, 2023

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