fubl-3

1. fubl-3 is required for lifespan in worms.

   “Loss of fubl-3 disrupts chromatin compaction and abolishes stress-induced lifespan extension”

   Model organismsmitochondrial stress; shown by loss of fubl-3

   FUBL-3/FUBP1 mediates mitochondrial stress-induced chromatin remodeling and longevity

   Science advances·Jun 24, 2026

2. fubl-3 extends lifespan in worms.

   “while its overexpression is sufficient to restructure chromatin, trigger UPRmt, and extend lifespan.”

   Model organismsoverexpression

   FUBL-3/FUBP1 mediates mitochondrial stress-induced chromatin remodeling and longevity

   Science advances·Jun 24, 2026

1. fubl-3 activates mitochondrial unfolded protein response in worms.

   “FUBL-3 translocates to intestinal nuclei upon stress, where it drives nucleosome remodeling and deacetylase-dependent chromatin condensation and activates mitochondrial unfolded protein response (UPRmt).”

   Model organismsintestine

   FUBL-3/FUBP1 mediates mitochondrial stress-induced chromatin remodeling and longevity

   Science advances·Jun 24, 2026

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