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dos-3

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Major Research Plan and 5 more
  • Model organisms1

Effects

2

Notch signalling

upin worms1

1 study

  1. dos-3 activates notch signalling in worms.

    “mediates the effect of the cell-non-autonomous DAF-16/FOXO activity on GSPC maintenance through activating Notch signaling in the germ line”

    Model organismsgerm line

    DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells

    Nature communicationsJun 8, 2024

More on Notch signalling

Stem cell maintenance

mediatesin worms1

1 study

  1. dos-3 mediates stem cell maintenance in worms.

    “dos-3, which encodes a non-canonical Notch ligand, is a direct transcriptional target of DAF-16/FOXO and mediates the effect of the cell-non-autonomous DAF-16/FOXO activity on GSPC maintenance”

    Model organismsgerm line

    DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells

    Nature communicationsJun 8, 2024

More on Stem cell maintenance

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