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DLX3

Gene

1 paper studies it3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Dental and Craniofacial Research and 2 more
  • Cells1

Effects

2

Cellular senescence

downin human cells1downin mouse cells1

1 study

  1. DLX3 decreases cellular senescence in mouse cells.

    “Both DLX3 mutations (c.533 A>G and c.571_574delGGGG) delayed cellular senescence when they were introduced into pre-osteoblastic cells MC3T3-E1.”

    Cellsc.533 A>G and c.571_574delGGGG in MC3T3-E1 cells

    Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome

    Scientific reports

  2. DLX3 decreases cellular senescence in human cells.

    “DLX3 mutation (c.533 A>G; Q178R) attenuates osteogenic potential and senescence of bone mesenchymal stem cells (BMSCs) isolated from a TDO patient”

    CellsBMSCs isolated from a TDO patient

    Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome

    Scientific reports

More on Cellular senescence

Bone loss

downin mice1

1 study

  1. DLX3 prevents bone loss in mice.

    “DLX3 (Q178R) transgenic mice not only reconfirmed that DLX3 mutation (Q178R) delayed cellular senescence, but also prevented aging-mediated bone loss.”

    Animalsaging-mediated bone loss in transgenic mice

    Senescence: novel insight into DLX3 mutations leading to enhanced bone formation in Tricho-Dento-Osseous syndrome

    Scientific reports

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