Brain
Brain inhibition shifts with age in gene-deficient female mice
Experiments in female mice with a mixture of cells with and without gene function found different age-related patterns in two brain regions.Experiments in female mice with a mixture of cells with and without gene function found different age-related patterns in two brain regions.
Mouse studyMechanisms
Who was studiedHeterozygous Cdkl5-deficient female mice
What changedInhibitory signaling first strengthened then weakened with age in mosaic female mice’s hippocampus, but increased in the middle-aged cortex
The catchAge-group differences could reflect cohort differences rather than changes within individual mice