BICD2

BICD2 has no effect on motor neuron degeneration in mice.

“BICD2-N mice did not develop signs of motor neuron degeneration and motor abnormalities.”

Animalsin transgenic mice expressing BICD2-N

A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice

Human molecular genetics·25 Jun 2008

BICD2 extends lifespan in mice.

“Interestingly, the BICD2-N transgene increased lifespan in 'low copy' SOD1-G93A ALS transgenic mice.”

Animalsin 'low copy' SOD1-G93A ALS transgenic mice

A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice

Human molecular genetics·25 Jun 2008