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ALS2

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funder: Japan Society for the Promotion of Science
  • Animals1

Effects

2

Spontaneous rearing activity

downin mice1

1 study

  1. ALS2 decreases spontaneous rearing activity in mice.

    “B6 female, but not male, Als2(-/-) mice showed a significantly lower spontaneous rearing activity than wild-type litters.”

    Animalson B6 backgroundfemales

    Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

    Neuroscience research14 Jun 2010

Lifespan

downin mice1

1 study

  1. ALS2 shortens lifespan in mice.

    “Als2(-/-) mice on a FVB, but not a B6, background exhibited a shorter life span than wild-type litters.”

    Animalson FVB background

    Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

    Neuroscience research14 Jun 2010

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