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Afr3

Gene

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Allergy and Infectious Diseases and 3 more
  • Model organisms1

Effects

1

Fluconazole resistance

upin C. neoformans cells1upin yeast cells1

1 study

  1. Afr3 increases fluconazole resistance in yeast cells.

    “The ADΔ + Afr3 strain demonstrated a higher efflux with both Rhodamine 6G and Nile red, and a higher FLC resistance.”

    Cellsheterologous expression in S. cerevisiae ADΔ

    Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans

    Journal of fungi (Basel, Switzerland)Jun 28, 2022

  2. Afr3 increases fluconazole resistance in C. neoformans cells.

    “The Δafr3 mutant strain showed higher FLC susceptibility by FLC E-Test strip testing and also by a killing test that measured survival after 3 h FLC exposure.”

    Cellsdeletion (Δafr3)

    Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans

    Journal of fungi (Basel, Switzerland)Jun 28, 2022

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