What does the research say about ADCY9?

ADCY9

There are 3 papers on ADCY9 in aging research: 1 observational study in people, 2 in animals.

3 papers study it2 findings

“Association analyses on chromosome 16 showed that the strongest variant resides within the ADCY9 gene.”

Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family StudyThe journals of gerontology. Series A, Biological sciences and medical sciences2021doi:10.1093/gerona/glab177

None of its findings points the other way.

Neuron regeneration and differentiation

upin D. japonica1

1 study

ADCY9 increases neuron regeneration and differentiation in D. japonica (shown by RNAi knockdown).
“significant inhibition of the regeneration and differentiation of multiple neuron types”
Model organismsshown by RNAi knockdowncephalic ganglia
ADCY9 Regulates Neural Stem Cells Via Mitofusin-1 to Maintain Planarian (Dugesia japonica) Cephalic Ganglia Regeneration
CellsFeb 24, 2026

Gait speed decline

upin humans1

1 study

ADCY9 is associated with gait speed decline in humans.
“Association analyses on chromosome 16 showed that the strongest variant resides within the ADCY9 gene.”
Humans7 ± 1 yearsn = 2,379
Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study
The journals of gerontology. Series A, Biological sciences and medical sciencesJun 23, 2021