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ACC

Gene

3 papers3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 2 more
  • Animals1
  • Model organisms2

Effects

3

Egg production

downin R. prolixus1

1 study

  1. ACC decreases egg production in R. prolixus (60% fewer eggs, 7% hatched vs 89%).

    “The AccKD females laid 60% fewer eggs than the control ones, and only 7% hatched (89% for control)”

    Model organismsknockdownfemales

    Deficiency of Acetyl-CoA Carboxylase Impairs Digestion, Lipid Synthesis, and Reproduction in the Kissing Bug Rhodnius prolixus

    Frontiers in physiologyJul 22, 2022

Lipid and ceramide metabolism

downin R. prolixus1

1 study

  1. ACC decreases lipid and ceramide metabolism in R. prolixus.

    “Their fat bodies showed reduced de novo lipogenesis activity, did not accumulate triacylglycerol during the days after blood meal, and had smaller lipid droplets.”

    Model organismsknockdownfat bodyfemales

    Deficiency of Acetyl-CoA Carboxylase Impairs Digestion, Lipid Synthesis, and Reproduction in the Kissing Bug Rhodnius prolixus

    Frontiers in physiologyJul 22, 2022

More on Lipid and ceramide metabolism

Lifespan

downin R. prolixus1

1 study

  1. ACC shortens lifespan in R. prolixus.

    “The knockdown (AccKD) females had delayed blood digestion and a shorter lifespan.”

    Model organismsknockdownfemales

    Deficiency of Acetyl-CoA Carboxylase Impairs Digestion, Lipid Synthesis, and Reproduction in the Kissing Bug Rhodnius prolixus

    Frontiers in physiologyJul 22, 2022

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