Subsequent primary lung cancer

1. Bladder cancer is associated with subsequent primary lung cancer in humans (Bladder cancer survivors) (6-year absolute risk 2.6%, above commonly used lung screening eligibility thresholds).

   “For survivors of head and neck or bladder cancers, the 6-year absolute risks of developing SPLC were 2.7% and 2.6%, respectively,”

   HumansBladder cancer survivors6 years

   Survivors of other cancers had higher lung cancer risk

   Clinical lung cancer·Oct 13, 2026

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1. Head and neck cancer is associated with subsequent primary lung cancer in humans (Head and neck cancer survivors) (6-year absolute risk 2.7%, above commonly used lung screening eligibility thresholds).

   “For survivors of head and neck or bladder cancers, the 6-year absolute risks of developing SPLC were 2.7% and 2.6%, respectively,”

   HumansHead and neck cancer survivors6 years

   Survivors of other cancers had higher lung cancer risk

   Clinical lung cancer·Oct 13, 2026

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1. Non-lung first primary cancer is associated with subsequent primary lung cancer in humans (Survivors of non-lung first primary cancers who survived at least 6 months) (SIR 1.37, 95% CI 1.32–1.42 versus people without a personal cancer history).

   “have a higher risk of developing SPLC compared to those without a personal cancer history overall (SIR = 1.37, 95% Confidence Interval: 1.32-1.42)”

   HumansSurvivors of non-lung first primary cancers who survived at least 6 monthsn = 180,325

   Survivors of other cancers had higher lung cancer risk

   Clinical lung cancer·Oct 13, 2026

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