Severe asthma
4 papers6 findings
- Humans2
- Cells1
- In silico1
Effects
3AURKA
upin mice1
1 study
AURKA
upin mice1
Severe asthma increases AURKA in mice.
“protein expression levels of ETS2, ETS1 and AURKA were increased in the severe asthma mouse model”
Animalsin severe asthma mouse model
GeneApr 24, 2024
ETS2
upin mice1
1 study
ETS2
upin mice1
Severe asthma increases ETS2 in mice.
“protein expression levels of ETS2, ETS1 and AURKA were increased in the severe asthma mouse model”
Animalsin severe asthma mouse model
GeneApr 24, 2024
ETS1
upin mice1
1 study
ETS1
upin mice1
Severe asthma increases ETS1 in mice.
“protein expression levels of ETS2, ETS1 and AURKA were increased in the severe asthma mouse model”
Animalsin severe asthma mouse model
GeneApr 24, 2024
Associations
3Cellular senescence
upin humans1
1 study
Cellular senescence
upin humans1
Severe asthma is associated with cellular senescence in humans.
“p53 and SASP ES were significantly elevated in bronchial biopsies of severe asthmatics compared to mild-to-moderate asthmatics and healthy volunteers”
Humanssevere asthmabronchial biopsy
Clinical Features of Cellular Senescence Pathways in Severe Asthma
AllergyJun 18, 2026
ADCK5
upin silico1
1 study
ADCK5
upin silico1
ADCK5 predicts severe asthma in silico.
“ADCK5 was identified as a highly expressed senescence-related marker in severe asthma, exhibiting both strong predictive value for the condition”
In silico
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence
International immunopharmacologyAug 29, 2025
IL15
upin humans1
1 study
IL15
upin humans1
Severe asthma is associated with IL15 in humans.
“airway IL15 expression was higher in patients with SA compared with MMA.”
Humanssevere asthmaairway
CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest
JCI insightMar 6, 2025
Trial sponsors
Company1 trialPhase 3310 people
University of Texas Southwestern Medical Center
1 trialPhase 426 people
Funding
4 grants since 2017Japan Society for the Promotion of ScienceJP¥8.6mOffice of the President, University of CaliforniaUS$2m
Regulation of obesity related severe asthma, role of glucagon-like peptide-1
Japan Society for the Promotion of ScienceSaga UniversityJP¥4m2020–2024
GLP-1 Agonists in Severe Asthma
Office of the President, University of CaliforniaUniversity of California, DavisUS$1m2018–2022
GLP-1 Agonists in Severe Asthma
Office of the President, University of CaliforniaUniversity of California, DavisUS$1m2018
Molecular mechanisms of steroid resistance in severe asthma with obesity
Japan Society for the Promotion of ScienceDokkyo Medical UniversityJP¥4.6m2017–2020