Secondary infertility

1. FOXO3 protects against secondary infertility in mice.

   “Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility.”

   Animalsin Foxo3a-/- micefemales

   Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a

   Science (New York, N.Y.)·11 Jul 2003

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