Phenylketonuria

Phenylketonuria is associated with cognitive function in humans.

“poorer cognitive performance alongside a higher prevalence of mood disorders and reduced quality of life, despite treatment.”

Reviewin adults with PKU

Mechanisms of Aging in Phenylketonuria (PKU)

American journal of medical genetics. Part A·15 Sep 2026

Phenylketonuria is associated with bone mineral density in humans.

“They also tend to demonstrate lower bone mineral density, more extensive white matter changes, and poorer cognitive performance alongside a higher prevalence of mood disorders”

Reviewin adults with PKU

Mechanisms of Aging in Phenylketonuria (PKU)

American journal of medical genetics. Part A·15 Sep 2026

Phenylketonuria is associated with arterial stiffness in humans.

“Adults with PKU exhibit greater cardiovascular aging, including arterial stiffness and dyslipidaemia, alongside higher rates of obesity, diabetes, and hypertension compared to adults without PKU.”

Reviewin adults with PKU

Mechanisms of Aging in Phenylketonuria (PKU)

American journal of medical genetics. Part A·15 Sep 2026