Microscopic polyarteritis

1. MICA raises the risk of microscopic polyarteritis in humans (Z = 3.702, p < 0.001, mediation effect = 72.1%).

   Humansmediated by upregulating DNAmAANKR NK cells

   Impact of Infection-Related Immune Responses on ANCA-Associated Vasculitis in Finns: A Mendelian Randomization Study · Genetics research · 1 Jan 2026

MICA →

1. MDC1 lowers the risk of microscopic polyarteritis in humans (Z = -3.310, p = 0.001, mediation effect = 81.5%).

   Humansmediated by downregulating DNAmAAdendritic cells

   Impact of Infection-Related Immune Responses on ANCA-Associated Vasculitis in Finns: A Mendelian Randomization Study · Genetics research · 1 Jan 2026

MDC1 →

1. HLA-C lowers the risk of microscopic polyarteritis in humans (Z = -2.921, p = 0.003, mediation effect = 82.2%).

   Humansmediated by downregulating DNAmAACD8nc T cells

   Impact of Infection-Related Immune Responses on ANCA-Associated Vasculitis in Finns: A Mendelian Randomization Study · Genetics research · 1 Jan 2026

HLA-C →

1. anti-HSV1 IgG lowers the risk of microscopic polyarteritis in humans (OR: 0.499, 95% CI: 0.361-0.692).

   HumansMendelian randomization

   Impact of Infection-Related Immune Responses on ANCA-Associated Vasculitis in Finns: A Mendelian Randomization Study · Genetics research · 1 Jan 2026

anti-HSV1 IgG →