Human malignancies

1. mTOR signalling raises the risk of human malignancies in humans.

   “constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes (mTORC1 and mTORC2) or upstream targets is responsible for aging, neurological diseases, and human malignancies.”

   Reviewconstitutive activation due to mutations/amplification/deletion

   Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

   Signal transduction and targeted therapy·2 Oct 2023

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