Hepatic impairment

Hepatic impairment decreases clearance in humans.

“In patients with hepatic impairment, the apparent clearance of everolimus is significantly lower than in healthy volunteers, and therefore the dosage of everolimus should be reduced by half in these patients.”

Reviewin patients with hepatic impairment

Clinical pharmacokinetics of everolimus

Clinical pharmacokinetics·1 Jan 2004