Neurobiology of Disease
Daily rhythm disruption differed by sex and mutation in aged mice
Wheel-running experiments in aged mice with two kinds of gene disruption revealed differences in activity levels, timing and the stability of daily rhythms.Wheel-running experiments in aged mice with two kinds of gene disruption revealed differences in activity levels, timing and the stability of daily rhythms.
Mouse studyMechanisms
Who was studiedAged mice with ADNP disruption
What changedDaily rhythms differed by sex, with lower activity in males and shifted timing in females; another mutation showed arrhythmicity under challenge
The catchComplete loss of detectable rhythms occurred only in an exploratory cohort of males