White matter grade

1. NfL predicts white matter grade in humans (RR 1.24, p = 0.0022).

   “log2(NfL) concentration was associated with WMG (β = 0.27; p = 2.3 × 10−4) and worsening WMG (relative risk [RR] 1.24; p = 0.0022)”

   Humanswithout a history of TIA or strokeserumn = 1,279

   Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study

   Neurology·Dec 17, 2021

2. NfL is associated with white matter grade in humans (β = 0.27, p = 2.3 × 10−4).

   “In fully adjusted models, log2(NfL) concentration was associated with WMG (β = 0.27; p = 2.3 × 10−4)”

   Humanswithout a history of TIA or strokeserumn = 1,362

   Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study

   Neurology·Dec 17, 2021

More on NfL

1. GFAP is associated with white matter grade in humans.

   “For the other 3 biomarkers, the associations for log2 (GFAP) concentration with WMG and worsening WMG were significant.”

   Humanswithout a history of TIA or strokeserumn = 1,279

   Association of Serum Neurofilament Light Chain Concentration and MRI Findings in Older Adults: The Cardiovascular Health Study

   Neurology·Dec 17, 2021

More on GFAP