There are 2 papers on type 2 diabetes polygenic score in aging research: 2 observational studies in people.
2 papers study it1 more mentions it5 findings
See all 3 papers on type 2 diabetes polygenic score
“The difference in diabetes prevalence between the top and bottom deciles of genetic susceptibility increased over time for all age groups.”
- Humans2
Effects
1Incident type 2 diabetes prediction
upin humans1
1 study
Incident type 2 diabetes prediction
upin humans1
Type 2 diabetes polygenic score is linked with better incident type 2 diabetes prediction in humans (C-index from 0.67 to 0.71).
“and C-index from 0.67 to 0.71 (both p < 0.001).”
Humansmedian follow-up of 4.6 yearsn = 12,174
Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older
Diabetes, obesity & metabolism
Associations
3Type 2 diabetes
upin humans1HR 1.55
1 study
Type 2 diabetes
upin humans1HR 1.55
Type 2 diabetes polygenic score predicts type 2 diabetes in humans (HR 1.55, 95% CI 1.40-1.71).
“and incident (hazard ratio: 1.55 [1.40-1.71]) T2D.”
Humansmedian follow-up of 4.6 yearsn = 12,174
Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older
Diabetes, obesity & metabolism
Type 2 diabetes polygenic score is associated with type 2 diabetes in humans (OR 2.39, 95% CI 2.19-2.61).
“Per standard deviation, the PGS was significantly associated with baseline (odds ratio: 2.39 [95% CI: 2.19-2.61])”
Humansn = 12,174
Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older
Diabetes, obesity & metabolism
Type 2 diabetes incidence
upin humans1
1 study
Type 2 diabetes incidence
upin humans1
Type 2 diabetes polygenic score is associated with type 2 diabetes incidence in humans (Top decile of genetic susceptibility; temporal trend).
“Additional analyses suggested an increasing diabetes incidence in participants aged 20-39 years in the top decile of genetic susceptibility”
HumansTop decile of genetic susceptibility; temporal trend
The lancet. Diabetes & endocrinology
Type 2 diabetes prevalence
upin humans1
1 study
Type 2 diabetes prevalence
upin humans1
Type 2 diabetes polygenic score is associated with type 2 diabetes prevalence in humans (Comparison of top and bottom deciles of genetic susceptibility over time) (Prevalence increased 9.1 percentage points (95% CI 8.0–10.1) in the top decile versus 0.4 percentage points (0.1–0.7) in the bottom decile).
“The difference in diabetes prevalence between the top and bottom deciles of genetic susceptibility increased over time for all age groups.”
HumansComparison of top and bottom deciles of genetic susceptibility over timemid-1980s to late 2010sn = 86,194
The lancet. Diabetes & endocrinology