What does the research say about system-specific biological dysregulation?

System-specific biological dysregulation

There is 1 paper on system-specific biological dysregulation in aging research: 1 observational study in people. The newest story, Nov 3, 2026: “Combined biological imbalances linked to disease and death”.

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1 paper studies it3 findings

1 new paper in 30 daysSee all 1 papers on system-specific biological dysregulation

“exhibit distinct associations with health risk factors, indicators and outcomes, and DNA methylation patterns.”

Humans1

Associations

Mortality

upin humans1

1 study

System-specific biological dysregulation is associated with mortality in humans (cumulative system-specific dysregulation).
“the effect of systems-specific dysregulation is cumulative, resulting in a significantly higher risk of disease incidence and death in older adults.”
Humanscumulative system-specific dysregulationn = 9,992
Combined biological imbalances linked to disease and death
bioRxivNov 3, 2026Preprint

Disease incidence

upin humans1

1 study

System-specific biological dysregulation is associated with disease incidence in humans (cumulative system-specific dysregulation).
“the effect of systems-specific dysregulation is cumulative, resulting in a significantly higher risk of disease incidence and death in older adults.”
Humanscumulative system-specific dysregulationn = 9,992
Combined biological imbalances linked to disease and death
bioRxivNov 3, 2026Preprint

DNA methylation patterns

mixedin humans1

1 study

System-specific biological dysregulation is associated with DNA methylation patterns in humans.
“exhibit distinct associations with health risk factors, indicators and outcomes, and DNA methylation patterns.”
Humansn = 9,992
Combined biological imbalances linked to disease and death
bioRxivNov 3, 2026Preprint

Latest

1 paper in 12 months

bioRxivNov 3

Combined biological imbalances linked to disease and death

An observational study of 9,992 older adults linked imbalances across multiple biological systems to a higher risk of developing disease and dying.An observational study of 9,992 older adults linked imbalances across multiple biological systems to a higher risk of developing disease and dying.

Preprint: cohort · 9,992 peopleBiomarkers

Paper

System-specific biological dysregulation

Associations

Latest

Combined biological imbalances linked to disease and death

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