There are 2 papers on spatial information score in aging research: none in people yet, 2 in animals. The newest story, Nov 2, 2026: “Brain cells signaled location less clearly in Alzheimer’s-model mice”.
2 papers study it1 more mentions it2 findings
APP
downin mice1
APP decreases spatial information score in mice during exploration of open field arenas.
“Spatial information scores are decreased in APP KI MEC neurons versus age-matched controls.”
Animalsduring exploration of open field arenasmedial entorhinal cortex
Brain cells signaled location less clearly in Alzheimer’s-model mice
Cell reports
3xTg-AD
downin mice1
3xTg-AD decreases spatial information score in mice.
“CA1 neuronal populations of 3xTg-AD mice show lower spatial information scores compared with control mice.”
AnimalsCA1
Neurobiology of disease
Recordings from seven 18-month-old Alzheimer’s-model mice and eight age-matched controls revealed poorer location and speed signals during arena exploration.Recordings from seven 18-month-old Alzheimer’s-model mice and eight age-matched controls revealed poorer location and speed signals during arena exploration.