Somatic TARDBP variants
Biomarker1 paper1 finding
- Humans1
Associations
1Frontotemporal lobar degeneration
upin humans1
1 study
Frontotemporal lobar degeneration
upin humans1
Frontotemporal lobar degeneration is associated with somatic TARDBP variants in humans.
Humanssporadic FTLD-TDP type C patients vs controlssuperior temporal gyrus
Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains · bioRxiv : the preprint server for biology · 22 Sep 2026 · Preprint
Latest
1bioRxivHumansPreprint
Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who…Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.