American Journal of Physiology Heart and Circulatory Physiology
Disabling an enzyme may improve brain artery function in aged mice
In an experiment in 18-month-old mice with a partial enzyme deficiency, disabling a second enzyme in blood-vessel lining cells improved abnormal artery responses.In an experiment in 18-month-old mice with a partial enzyme deficiency, disabling a second enzyme in blood-vessel lining cells improved abnormal artery responses.
Mouse studyMechanisms
Who was studiedAged mice with partial eNOS deficiency
What changedDisabling BACE1 changed brain artery responses to acetylcholine from contraction to moderate relaxation
The catchThe blood–brain barrier result measured protein expression rather than barrier function