Skeletal Muscle Gauge

1. Skeletal Muscle Gauge predicts mortality in humans (HR 2.34, 95% CI 1.48-3.69; p < 0.001).

   “SMG values < 87,816 AU were associated with significantly worse survival in both sexes (HR 2.34, 95% CI 1.48-3.69; p < 0.001).”

   Humansresected clinical stage I-IIB NSCLCn = 343

   Skeletal Muscle Gauge as a Prognosticator of Survival in Resected Early-Stage Non-small Cell Lung Cancer

   Annals of surgical oncology·Oct 15, 2025

2. Skeletal Muscle Gauge is associated with mortality in humans (OR 2.12, 95% c.i. 1.18 to 3.83, P = 0.012).

   “low SMG was associated with worse 30- and 90-day mortality, with odds ratios of 2.12 (95% confidence interval (c.i.) 1.18 to 3.83; P = 0.012)”

   Humansemergency laparotomy30-dayn = 1,090

   Evaluation of sarcopenia and myosteatosis to determine the impact on mortality after emergency laparotomy

   BJS open·Jul 1, 2025

1. Skeletal Muscle Gauge is associated with length of hospital stay in humans (OR 1.45, 95% c.i. 1.22 to 1.72, P < 0.001).

   “Low SMG was also associated with an increased length of hospital stay (odds ratio 1.45; 95% c.i. 1.22 to 1.72; P < 0.001).”

   Humansemergency laparotomyn = 1,090

   Evaluation of sarcopenia and myosteatosis to determine the impact on mortality after emergency laparotomy

   BJS open·Jul 1, 2025

1. Skeletal Muscle Gauge predicts sarcopenia in humans (AUC 0.87‒0.88 vs 0.80‒0.82, P < .05).

   “SMG outperformed SMI in diagnostic accuracy in all regions, particularly for L3 (AUC: 0.87‒0.88 vs 0.80‒0.82; both P < .05).”

   Humansgastrointestinal disorders with or without cancerskeletal musclen = 385

   Diagnostic Value of Sarcopenia Computed Tomography Metrics for Older Patients with or without Cancers with Gastrointestinal Disorders

   Journal of the American Medical Directors Association·Dec 2, 2022

More on Sarcopenia

1. Age is associated with Skeletal Muscle Gauge in humans (r=-0.45).

   “Increased age moderately correlated with decreased skeletal muscle gauge (r=-0.45).”

   Humansadvanced stage (IIIC/IV) ovarian cancerfemalesn = 429

   Quality is more important than quantity: pre-operative sarcopenia is associated with poor survival in advanced ovarian cancer

   International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·Jun 10, 2022

1. Skeletal Muscle Gauge predicts overall survival in humans (HR 1.27 (95% CI 1.12 to 1.44) per 1-unit decrease in z-score).

   “Decreasing skeletal muscle density and skeletal muscle gauge were significantly associated with increased risk of death; HR (95% CI) per 1-unit decrease in z-score of 1.24 (1.10 to 1.39) for skeletal muscle density and 1.27 (1.12 to 1.44) for skeletal muscle gauge.”

   Humansadvanced stage (IIIC/IV) ovarian cancerpre-operative CT imagingskeletal musclefemalesn = 429

   Quality is more important than quantity: pre-operative sarcopenia is associated with poor survival in advanced ovarian cancer

   International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·Jun 10, 2022

1. Frailty is associated with Skeletal Muscle Gauge in humans (1188 versus 922 AU in robust versus frail patients; p=0.003).

   “Significant differences were found between robust and frail patients for SMD (29.4 vs 24.1 HU, p<0.001) and SMG (1188 vs 922AU, p=0.003)”

   HumansRobust versus frail patients with cancerskeletal musclen = 162

   Frailty and skeletal muscle in older adults with cancer

   Journal of geriatric oncology·Aug 24, 2017